Learn how Natural Killer Cells combat age-related illnesses like cell senescence. Discover the role of NK cells in preventing age-related disorders in this informative video. Summary In this episode of Drug Diaries, host Kaushik Trivedi explores the impact of natural killer cells on age-related diseases. He discusses a study that shows the prevalence of frailty and physical dysfunction in older adults and introduces Cellularity Inc., a biotech company studying natural killer cells for their potential in fighting age-related diseases. Trivedi then delves into the science behind cellular senescence, explaining how cells can become damaged and the different responses to that damage. He discusses the concept of senescence and its role in preventing cancer, as well as the negative effects of accumulated senescent cells on human health. The episode concludes with an invitation for innovators to share their groundbreaking work on Drug Diaries. Citations https://celularity.com/celularity-to-present-data-showing-senescent-cell-elimination-by-off-the-shelf-natural-killer-cells-derived-from-human-placental-cells/ SENS Research Foundation - https://www.sens.org/ https://www.nature.com/articles/d41586-024-01370-4#:~:text=Lurking%20throughout%20your%20body%2C%20from,and%20weaken%20the%20immune%20system. Keywords natural killer cells, age-related diseases, frailty, physical dysfunction, cellular senescence, DNA damage, cancer prevention, inflammation, senescence-associated secretory phenotype, accumulation of senescent cells, drug therapies, cell therapies, innovators Takeaways Natural killer cells are being studied for their potential to fight age-related diseases. Cellular senescence is a response to cellular damage and can prevent cancer. Senescent cells can have negative effects on other cells and tissues due to inflammation. Accumulated senescent cells may worsen conditions such as Alzheimer's disease, heart disease, and liver fibrosis. Research is being conducted to remove senescent cells with drugs or cell therapies. Drug Diaries invites innovators to share their groundbreaking work on the podcast. Titles Exploring Potential Therapies to Remove Senescent Cells The Impact of Natural Killer Cells on Age-Related Diseases Sound Bites "Natural killer cells are being studied for their potential to fight age-related diseases." "Cellular senescence is a great mechanism to have in our bodies, but too much of a good thing can become a bad thing." "Conditions such as Alzheimer's disease, heart disease, and liver fibrosis may be significantly worsened by the increased inflammation that comes with the accumulation of senescent cells." Chapters 00:00 Introduction to Drug Diaries 01:00 The Impact of Natural Killer Cells on Age-Related Diseases 03:51 Understanding Cellular Senescence and its Role in Cancer Prevention 06:45 The Negative Effects of Accumulated Senescent Cells on Human Health 07:13 Exploring Potential Therapies to Remove Senescent Cells 08:11 Inviting Innovators to Share Groundbreaking Work on Drug Diaries