We break down what the research says happens after stopping GLP-1 medications like semaglutide and tirzepatide, including the scale, hunger signals, and key lab changes. We explain the biology behind rebound and why weight regain is predictable physiology rather than a willpower problem.
• GLP-1s as long-term management for obesity and type 2 diabetes, not a cure
• what GLP-1 does in the brain, stomach, and pancreas and what reverses after stopping
• STEP 1 extension numbers showing about two-thirds regain over a year after stopping Wegovy
• meta-analysis findings on average regain after semaglutide or tirzepatide
• why bigger losses often come with bigger rebounds and why regain is typically gradual
• body composition concerns, regain tending to be more fat than muscle
• what happens to A1C, fasting glucose, blood pressure, and cholesterol after discontinuation
• set point, metabolic adaptation, and counter-regulatory appetite signals
• legitimate reasons people stop and why stopping should be a planned transition
You can find us on Instagram, threads. You can send us an in um a voicemail.

Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.

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Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN

Artwork Rebrand and Avatars:

Vantage Design Works (Vanessa Jones)

Website: https://www.vantagedesignworks.com/

Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qr

Original Artwork Concept: Olivia Pawlowski

We break down what continuous glucose monitors really measure and how to use CGM data without letting a new health metric run your life. We walk through a new primary care study in type 2 diabetes without insulin and talk honestly about benefits, limits, cost, and the questions the research still leaves open.
• separating A1C, fingerstick glucose, and CGM trend data
• why CGM readings can lag behind finger sticks
• what the Kinect trial studied and why it matters for non-insulin type 2 diabetes
• A1C changes, time in range, and what “better control” can mean day to day
• medication intensification versus behavior change as competing explanations
• sponsorship and study design caveats worth noticing
• using CGMs to spot meal spikes and guide realistic nutrition choices
• consumer CGMs for prediabetes curiosity and time-limited learning
• cost, access, and why long-term real-world results may differ
You can find us on Instagram, threads, send us an email, send us a voicemail if you'd like

Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.

Support the show

Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN

Artwork Rebrand and Avatars:

Vantage Design Works (Vanessa Jones)

Website: https://www.vantagedesignworks.com/

Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qr

Original Artwork Concept: Olivia Pawlowski

We break down the 5:2 diet in plain language and explain why it can work without any metabolic magic. We share what the research actually shows, how to do the low days safely, and who should pause and talk with their doctor first.
• what “five normal days, two low days” really means and why the low days should not be back to back
• why 5:2 works the same way other weight loss plans work through a weekly calorie deficit
• what studies show when 5:2 goes head to head with daily calorie cutting
• realistic expectations for weight loss and possible changes in blood pressure and blood sugar
• how to set up low days with protein, high-volume foods, fluids, and smart activity
• what hunger and other common low-day symptoms feel like and why they usually improve
• the real problem with long-term results being stick-with-it time
• when to talk to your doctor first including diabetes meds, eating disorder history, pregnancy, and frailty
You can find us on Threads, Instagram, or send us an email, or send us a voicemail, fan mail.

Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.

Support the show

Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN

Artwork Rebrand and Avatars:

Vantage Design Works (Vanessa Jones)

Website: https://www.vantagedesignworks.com/

Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qr

Original Artwork Concept: Olivia Pawlowski