Editor's note: Welcome to the 23rd episode of The Pain Beat, PRF's podcast series! The Pain Beat brings together the world's leading pain investigators in order to spark dialogue and debate around important ideas in pain research. The Pain Beat podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here.

This episode of the Pain Beat covers ion channel disorders known as channelopathies that underlie painful conditions. The conversation covers from human genetics, structural analyses, electrophysiological functional characterizations to personalized medicine and new therapeutic strategies.

Participants include:

Dr. Angelika Lampert, PhD, Aachen University, Germany

Dr. Candice Paulsen, PhD, Yale University, US

Dr. See Wan Tham, MD, Seattle Children's Hospital, US

Moderated and organized by Dr. John Del Rosario, PhD, Washington University in St. Louis, US.

This episode was produced by Lite Yang, Washington University in St. Louis, US and edited by Dieu Ni Doan, MD, PhD., Harvard Medical School

Music was provide by Kevin Seal of Seal Party.

Other episodes of the Pain Beat can be found on Apple Podcast, Spotify and the Pain Research Forum.

Editor's note: Welcome to the 22nd episode of The Pain Beat, PRF's podcast series! The Pain Beat brings together the world's leading pain investigators in order to spark dialogue and debate around important ideas in pain research. The Pain Beat podcasts feature open and spirited discussion about the hottest topics in pain and how the field moves forward from here.

On this episode, experts in pain research discuss the modification of pain by homeostatic drives and survival threats. How for example, do hunger and sleep modify the pain experience and how are they themselves modified by pain. What are the circuits and mechanisms underlying these interactions?

Participants on the podcast:

• Loren Martin, PhD, University of Toronto
• Nitsan Goldstein, PhD, MIT
• J. Nicholas Betley, PhD, University of Pennsylvania
• Alban Latremolier, PhD, Johns Hopkins University.
• Al Nie, Johns Hopkins University (Organizer and Moderator)

Music provided by Kevin Seal. Other episodes of the Pain Beat can be found on Apple Podcast, Spotify and the Pain Research Forum.

The first interview in the PRF Spotlight Series: Voices Shaping Pain Science features Dr. Michael Gold, PhD delving deep in to discussion of the history and future of sodium channels.

From the identification of sodium channels as drivers of nociceptor excitability to the emergence of NaVs as therapeutic targets, this conversation bridges the history of pain research with the future of mechanism-based analgesia.

Part 1 of our interviews on Sodium Channels and the Making of a Field.

Michael Gold, PhD

University of Pittsburgh

Francisco Isaac Gomes-Aragão, DDS, MSC, PhD

University of São Paulo, BR

Beatriz Lima Adjafre, PhD

University of São Paulo, Br

Music by Seal Party.