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Dr. Nero speaks with Dr. Greg Katz of NYU about the neutral topline results of the Lp(a) HORIZON trial and their implications for patient care. Beyond the trial readout, they explore how these findings reshape expectations that lowering Lp(a) will improve cardiovascular outcomes—and how to counsel and treat patients amid this uncertainty. They discuss current strategies, potential alternatives, and emerging therapies that may provide new answers. Although the results raise more questions than they resolve, the conversation remains centered on what matters most: patients.

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Dr Thomas Nero discusses treatments for hypertension with Dr Liffert Vogt focusing on lifestyle changes as well as new therapies

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In this conversation, Dr. Nehal Mehta and Dr. Thomas Nero discuss the critical relationship between systemic inflammation and cardiovascular health, particularly in patients with psoriasis. He emphasizes the importance of understanding how an overactive immune system can lead to increased risks of heart disease and other health issues. The discussion also covers lifestyle changes that can help manage inflammation, including diet, exercise, and mental health support.

takeaways

• Systemic inflammation can lead to cardiovascular disease.
• Psoriasis is linked to increased heart attack risk.
• Visceral fat contributes to inflammation and diabetes.
• Weight loss can improve response to treatment.
• Lifestyle changes are crucial for managing inflammation.
• Family support plays a role in health management.
• Mental health is important in managing chronic conditions.
• Dietary changes can significantly impact inflammation levels.
• Regular exercise is beneficial for heart health.
• Education and awareness are key for patients.

keywords

systemic inflammation, cardiovascular disease, psoriasis, immune system, lifestyle changes, diabetes, obesity, heart health, inflammation management, patient education