Few companies have as much influence over AI’s trajectory as OpenAI. Reid Hoffman sits down with CFO Sarah Friar to understand the precipice of the moment we are in and the decisions that could shape what comes next for each of us.

This conversation was recorded live as part of Masters of Scale Summit on October 21, 2026, at the Presidio Theatre in San Francisco.

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REI has been around for 88 years. Mary Beth Laughton wants to make sure it’s around for 88 more. The CEO of America’s largest consumer co-op joins Rapid Response to talk about what it actually takes to revive an iconic business — without shareholders, without quarterly earnings calls, and with 26 million members who hold you to a higher standard than any Wall Street analyst ever could. She explains why her first act as CEO was to publicly break ties with a Trump cabinet secretary, and how the co-op structure gives REI a kind of clarity that most retailers can’t buy. Plus lessons drawn from Nike, Sephora, and Athleta on what it really means to lead a mission-driven brand when the values are battle tested, not just stated.

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Rich Roll’s popular podcast recently passed 1,000 episodes. He sat down with host Jeff Berman to discuss his growing podcast network, why he’s ignoring the algorithm, and his tumultuous path from addiction to wellness and endurance athletics.

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Renee Wegrzyn spent her career building the future of American science — including ARPA-H, the White House agency created to accelerate health breakthroughs. Then the Trump administration showed her the door. Wegrzyn co-founded Transfyr to tackle what she calls one of the most overlooked issues in science: the magic hands problem. She joins Rapid Response to explain why fixing this unglamorous bottleneck is the prerequisite for everything AI promises to deliver in medicine, what the federal funding cuts are really costing science, and why she can feel the next Sputnik moment coming — even if she can’t quite name it yet.

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Thibault “Tibo” Sottiaux is OpenAI’s head of Product & Platform, making him responsible for the AI tools used by more than a billion users worldwide. Rana el Kaliouby spoke with Tibo on Pioneers of AI about why he’s “proud” OpenAI delayed its latest Astra model over safety concerns, the new suite of agentic products released at DevDay, and what it’s like to lead inside a frontier AI company in this extraordinary moment in history.

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Alyssa Ravasio loves using ‘coyote trickster energy’ to get more people to put down their technology. Her camping marketplace, Hipcamp, has grown into the largest source for booking campsites on public and private land. She talks with host Jeff Berman about scaling the company, learning to prioritize your health as a founder, and more.

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Prediction markets incentivize truth. Everything else incentivizes clickbait. That's the core argument Luana Lopes Lara makes for Kalshi — the prediction market platform she co-founded that has gone from $5 billion to $22 billion in valuation in under a year, and is now being sued by New York's attorney general for $36 billion. Luana joins Rapid Response to make the case that Kalshi is fundamentally different from DraftKings — even though 75% of its volume is sports — explain why George Santos got banned for trying to trade on his own congressional attendance, and share what Kalshi's data actually says about the midterms. Plus the Timothée Chalamet dentist-chair ad, what ballet taught her about running a company, and what it's actually like to become the world's youngest self-made female billionaire.

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Jennifer Ferro is the former board chair of NPR and president of Southern California’s iconic public radio organization: KCRW. Ferro talks with host Jeff Berman about how nearly two decades as the founder’s deputy taught her to lead, why she thinks we deserve a better internet, and how the best defense of getting ignored is simple: Don’t be boring.

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