In this episode of Rheuminations, host Adam Brown, MD, discusses the history and long line of discoveries that led to non-radiographic axial spondyloarthritis imaging and how that may or may not have helped diagnosis.

· Starting with classification criteria. 3:25

· Trying to understand ankylosing spondylitis 7:40

· Trouble with X-rays and diagnosis: A lack of radiographic evidence. 14:26

· How did MRI make a difference? 23:55

· A longitudinal study. 30:45

· NSAIDs roll out. 33:12

· Biologics help us classify non-radiographic axial SpA. 34:14

· Imaging as a necessity to diagnose. 37:52

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Ahlström H, et al. Arthritis Rheum. 1990;doi:10.1002/art.1780331202

Bollow M, et al. Radiology. 1995;doi:10.1148/radiology.194.2.7824736

Khan M A, et al. Arthritis Rheum. 1985;doi:10.1002/art.1780280107

Murphey M D, et al. Radiology. 1991;doi:10.1148/radiology.180.1.2052702

Oostveen J, et al. J Rheumatol. 1999; 26(9):1953-8.

Prakash S, et al. Ann Rheum Dis. 1983;doi:10.1136/ard.42.6.640

Rudwaleit M, et al. Ann Rheum Dis. 2004;doi:10.1136/ard.2003.011247

Rudwaleit M, et al. Ann Rheum Dis. 2009;doi:10.1136/ard.2009.108233

In this episode of Rheuminations, host Adam J. Brown, MD, untangles the confusing serologies of lupus by learning about their discoveries from the beginning. He answers questions like what's the deal with immunofluorescence patterns, why does SSA/SSB have two names (Ro/LA), and is double-stranded DNA antibody really attracted to both strands?

· The story of antibodies in lupus. 3:27

· The "LE" factor. 10:11

· The changing fluorescent patterns of the staining of the nucleus/ENAs. 18:50

· The anti-Smith antibody. 24:51

· The mysteries of SSA and SSB. 28:52

· Double-stranded DNA. 36:32

· Crithidia luciliae. 40:30

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Aarden LA, et al. Ann NY Acad Sci. 1975;doi:10.1111/j.1749-6632.1975.tb29197.x

Alspaugh MA, et al. Arthritis Rheum. 1976;doi:10.1002/art.1780190214

Aslpaugh MA, et al. J Clin Invest. 1975;doi:10.1172/JCI108007

Arana R, et al. J Clin Invest. 1967;doi:10.1172/JCI105677

Clark G, et al. J Immunol. 1969;PMED:4179557

Dubois EL, et al. Blood. 1957;doi:10.1182/blood.V12.7.657.657

Friou GJ, et al. J Immunol. 1958;doi:10.4049/jimmunol.80.4.324

Hargraves MM. Proc Staff Meet Mayo Clin. 1949;doi:10.1016/S0025-6196(25)08519-2

Haserick JR, et al. Am J Med Sci. 1950;doi:10.1097/00000441-195006000-00010

Rowell NR, et al. Arch Dermatol. 1963;doi:10.1001/archderm.1963.01590200064012

Tan EM, et al. J Clin Invest. 1966;doi:10.1172/JCI105479

Tsokos GC. J Immunol. 2006;doi:10.4049/jimmunol.176.3.1295

In this episode of Rheuminations, guest host Leonard H. Calabrese, DO, sits down with David Chernoff, MD, chief medical officer of SetPoint Medical, to discuss the vagus nerve and recent developments in immune mediated disease.

· The story of Kevin Tracey, MD. 5:08

· Going from cytokines to the vagus nerve to immune mediated inflammatory disease. 7:23

· The ups and downs of non-surgically implanted devices. 13:28

· The pivotal studies. 15:35

· Gadolinium MRI. 24:03

· The gut-brain immune axis. 29:35

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Leonard H. Calabrese, DO, can be reached at CALABRL@ccf.org. Follow him @LCalabreseDO.