Misty Copeland changed what was possible for generations of dancers to come. Jim and Kate sit down with Misty to talk about the determination it took to reach the top and why her focus today is on creating opportunity for others. They discuss motherhood and the work she's doing through The Misty Copeland Foundation to help young artists see themselves in spaces where they belong. This is a conversation about building something bigger than yourself.

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For Maimah Karmo, surviving cancer was just the beginning. In this episode of Get Real, Jim sits down with Maimah, founder and CEO of the Tigerlily Foundation, who is 20 years out from a diagnosis of stage two triple negative breast cancer. Maimah made a decision early on: she wasn’t just going to survive, she was going to live with intention. She shares how her upbringing, from Liberia to building a life in the U.S., shaped her instinct to advocate for herself and others. And how, after her first chemotherapy treatment, she began building Tigerlily with nothing but a question, a prayer, and a purpose. They get real about what it means to thrive after cancer — physically, mentally, and emotionally. From daily practices to discipline to building community. Maimah shows that longevity isn’t just about time.It’s about how you choose to live it.

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For decades, the biotech industry has been concentrated in a handful of coastal hubs. But according to Isaac Barchas, one of the most significant opportunities in medicine may be hiding in plain sight.In this episode of Get Real, Jim Weiss sits down with Isaac Barchas, co-founder of Arsenal Bridge Ventures, to discuss why world-class scientific research is happening far beyond Boston and Silicon Valley, and why investors have been overlooking it for years.Isaac shares Arsenal Bridge's mission to identify breakthrough discoveries emerging from universities and research institutions across America's heartland, provide the capital and leadership needed to commercialize them, and help transform promising science into life-changing therapies.Together, Jim and Isaac explore the future of biotech innovation, the challenges of building companies outside traditional venture capital hubs, and why investing in overlooked regions could be good for patients, good for business, and good for America.

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Dr. Cheri Mah has spent her career proving what elite athletes are finally starting to take seriously: sleep is not optional — it’s medicine. In this episode of Get Real, the internationally recognized sleep physician and researcher joins Jim to break down how sleep drives performance, recovery, injury prevention, and mental health, both in sports and in life. They explore why chronic sleep deprivation is quietly undermining health outcomes, how teams use sleep data to gain a competitive edge, and what everyday people can learn from the way professional athletes prioritize rest. From circadian rhythm to behavior change, this conversation reframes sleep not as a luxury, but as one of the most powerful and underestimated tools we have for human performance and well‑being.

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Few voices are as woven into Bay Area sports as Vern Glenn’s. In this episode of Get Real, the longtime broadcaster sits down with Jim to trace his journey to becoming one of the most recognizable storytellers in local television. Vern reflects on breaking into the business, making mistakes on air, and building a career defined by curiosity, humor, and hands‑on reporting — earning the nickname “Mr. Involvement.”

They talk about the pressures facing athletes, the power of sports for mental health and community, and why giving back through the Vern Glenn Invitational has become one of his proudest chapters. A warm, candid conversation about craft, longevity, and loving the work enough to keep showing up.

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Founder Len Kozhukh sees a new horizon of health - using a quick assessment of your oral microbiome to PREVENT THE EVENT, one of the pillars of this show. In a special in-person episode, Jim and Len discuss Len's company nihl and how Len hopes it can be the start of a longevity revolution. We need to free everyone's health data so you can be in the driver's seat - can our saliva be the key? Let's find out!

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Sean Khozin has lived through revolution, rebuilt from scratch, and gone on to help reshape modern oncology. In this episode of Get Real, Sean shares his journey from fleeing Iran as a child to leading at the highest levels of cancer research, regulation, and innovation at the NCI, FDA, Johnson & Johnson, and now as CEO of the CEO Roundtable on Cancer.

We explore why cancer is always personal, how AI can restore the doctor‑patient relationship, and why data must become liquid to unlock precision medicine. This is a wide‑ranging chat about science, freedom, music, and why the future of healthcare only works if it starts with the patient.

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Former FDA Commissioner, practicing cardiologist, and adjunct professor at Duke University, Dr. Robert Califf joins the conversation to unpack the complex world of public health, drug regulation, and medical innovation. He offers a clear-eyed perspective on how the U.S. Food and Drug Administration makes decisions that impact millions of lives. Dr. Califf explores the ongoing effort to build public trust in science and emphasizes why that trust is essential to better health outcomes. He also shares insight into the future of healthcare, from data-driven medicine to the role of prevention in improving outcomes across populations.

This episode is a thoughtful look at the systems that shape modern medicine and what it will take to make them work better for everyone.

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