Using a realistic patient case, this final episode demonstrates how expert clinicians evaluate, diagnose, and manage a patient with suspected adult HLH in real time. Faculty discuss the interpretation of evolving clinical findings, biomarkers, and imaging, while highlighting common diagnostic pitfalls, treatment escalation strategies, and the importance of identifying the underlying trigger. The case illustrates how multidisciplinary decision-making and early intervention can improve outcomes in this complex and rapidly evolving syndrome.

Launch/Release Date: July 23, 2026

Activity Expiration Date: June 30, 2027

Faculty

Sarah Nikiforow, MD, PhD

Assistant Professor, Stem Cell Transplantation

Medical Director, DFCI Cell Manipulation Core Facility

Technical Director, DFCI Immune Effector Cell Therapy Program

Dana-Farber Cancer Institute

Daniella Schwartz, MD

Assistant Professor

Division of Rheumatology and Clinical Immunology

Departments of Medicine and Immunology

Co-Director, Autoinflammatory Center of Excellence

Co-Director, Pittsburgh Immunogenetics Discovery Center

University of Pittsburgh Medical Center

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