Adult hemophagocytic lymphohistiocytosis (HLH) is a rapidly progressive hyperinflammatory syndrome that often presents with nonspecific features, making early diagnosis challenging. In this introductory episode, expert faculty explain the underlying immunobiology of adult HLH, distinguish primary from secondary disease, and explore why HLH should be viewed as a syndrome rather than a single disease entity. The discussion establishes the clinical framework needed to recognize patients at risk and prepares learners for the practical diagnostic and management strategies covered throughout the series.

Launch/Release Date: July 23, 2026

Activity Expiration Date: June 30, 2027

Faculty

Sarah Nikiforow, MD, PhD

Assistant Professor, Stem Cell Transplantation

Medical Director, DFCI Cell Manipulation Core Facility

Technical Director, DFCI Immune Effector Cell Therapy Program

Dana-Farber Cancer Institute

Daniella Schwartz, MD

Assistant Professor

Division of Rheumatology and Clinical Immunology

Departments of Medicine and Immunology

Co-Director, Autoinflammatory Center of Excellence

Co-Director, Pittsburgh Immunogenetics Discovery Center

University of Pittsburgh Medical Center

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