For more than two decades, 15 PSI has been treated as a key safety threshold for injection pressure during peripheral nerve blocks, but the evidence suggests it is more complicated than a single number. In this episode, we discuss a 2026 Journal of Clinical Anesthesia systematic review by De Cassai and colleagues, which analyzed 28 experimental studies on injection pressure and nerve injury. We look at how tissue compliance, needle design, and injection speed influence pressure readings, why opening injection pressure matters more than peak pressure, and whether pressure-time curves could shape the future of injection safety.

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Disclaimer: Medicine is an ever-changing science. As new research and clinical experience broaden, changes in treatment and drug therapy are required. The authors and publishers have checked with sources believed to be reliable in efforts to provide accurate information within the available or accepted standards of care. However, given the possibility of human error or changes in medical practice, neither the authors nor the publisher, nor any other party involved in the preparation of this platform warrants that the information contained herein is in every aspect accurate or complete, and they disclaim all responsibility for any errors or omissions for the results obtained from the use of the information contained in this work. Readers are advised to confirm the information contained herein with other sources. For example, readers are advised to check the product information of each drug mentioned, and that any information contained on NYSORA's Podcast is accurate.

Why is intravenous iron still underused in surgical patients despite growing evidence supporting its role in perioperative anemia management? We discuss the 2026 British Journal of Anaesthesia consensus recommendations, addressing hypersensitivity reactions, infusion safety, infection concerns, hypophosphatemia, and the importance of early preoperative anemia screening.

• Read more about the study ⁠⁠⁠⁠HERE⁠.

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Disclaimer: Medicine is an ever-changing science. As new research and clinical experience broaden, changes in treatment and drug therapy are required. The authors and publishers have checked with sources believed to be reliable in efforts to provide accurate information within the available or accepted standards of care. However, given the possibility of human error or changes in medical practice, neither the authors nor the publisher, nor any other party involved in the preparation of this platform warrants that the information contained herein is in every aspect accurate or complete, and they disclaim all responsibility for any errors or omissions for the results obtained from the use of the information contained in this work. Readers are advised to confirm the information contained herein with other sources. For example, readers are advised to check the product information of each drug mentioned, and that any information contained on NYSORA's Podcast is accurate.