A scorned serial killer on an old vendetta. An FBI agent who has been chasing monsters for too long. A woman whose nightmares start invading her waking life.

FBI special agent Jack Matthews finds himself on yet another serial killer case, having barely recovered from the last disastrous hunt. Still stiff from a gunshot wound in his leg, under investigation for a botched job, and having lost his fiancée when she walked out on him, Jack is beginning to wonder if it isn't time to move on to something new. But, for Jack, these cases are personal, and he can't say no.

Marketing specialist Kathy Gilliam leads a fairly boring life. If she's not working or caring for her ailing father, then she is doing whatever it takes to avoid going anywhere near crowds of people. Her few distractions include her friend Margo Longfellow, occasional hiking trips, and her increasingly alarming dreams of women dying. As her nightmares cause her to begin to doubt her sanity, the media releases news of the "coast-to-coast killer", and Kathy discovers her dreams may be related.

In a moment of panic, Kathy does something that places her on FBI's "persons of interest" list. Suddenly, her life is set on a collision course with Jack who must decide if Kathy is the killer or destined to become a victim.