For centuries, would-be explorers have examined a document written in 1753 rumored to hold the key to locating the so-called Lost City of Z, a fortified settlement containing many treasures and built entirely of gold. Thought to be buried somewhere within the Mato Grosso region of the Amazon rain forest, the lure of the vanished riches has long proven deadly to treasure seekers who brave the forbidding wilderness and mysterious creatures in search of it.

Disgraced historian Dr. Hunter Winslow, fired from a lucrative professorship for stealing rare documents in order to gain a competitive edge over his colleagues, thinks the key to Manuscript 512 lies not in its words, but in its paper itself. The only problem is that to confirm his hypothesis means to destroy the document, something the Brazil National Library in Rio de Janeiro will never allow. But old habits die hard, and Hunter knows his way around a special collections room. After a brazen theft that triggers an international manhunt, the rogue historian is able to reveal the document’s secrets in a way no one else can or ever will be able to again - by using its physical properties to reveal missing sections that had supposedly been irreversibly damaged.

Armed with this new information, Hunter embarks on an expedition to the deepest Amazon to put to rest the mystery of the lost city once and for all. But while Hunter is looking for the fabled treasure, the long arm of the law is looking for him. Will they catch up to him before he can locate the treasure of a thousand lifetimes, or will he become as lost as the city he seeks?