Stockbroker Isabelle Rhodes has a lot of money, a lot of trust issues, and a whole lot of reasons to believe her ex-girlfriend was right when she said that Isabelle sucked at relationships. With that accusation stuck in her head, Isabelle throws caution to the wind and dives into her first one-night stand. Checking that off her bucket list should be something to celebrate - except it turns out that the woman she just spent an earth-shattering night with is actually her newly hired company pilot, Audrey Graham. Ms. Never-See-You-Again just turned into Ms. See-You-Constantly.

After nearly a decade as a professional drummer, Diana Petrell leaves her rock-star life behind to continue her residency in emergency medicine. She's determined not to let anything stop her - not even falling in love with her aloof mentor, Dr. Emily Barnes. Emily has only ever focused on her career as a senior attending in the emergency department, and she isn't happy about having to babysit a resident with a 10-year gap in her resume, no matter how intriguing she is. But every time they work together, it's not just their patients' heartbeat that gets a little irregular.

Vivian Barrera, a professional woman focused on her company's success, doesn't know what to think when her sometimes-lover and long-time business partner Jack hires someone without her permission. The only thing she does know is that she doesn't like the newcomer. April Hawkins is determined to make her new job work. Left as the sole provider for her niece, she just wants to keep her head down and collect her paycheck. That proves to be difficult when one of her bosses seems to hate her and the other seems to like her a little too much.

Life has become a farcical mess for icy British A-lister Elizabeth Thornton. America's most-hated villain stars in a top-rated TV medical drama that she hates. Now, she's been romantically linked to her perky, new co-star, Summer, due to the young woman's clumsiness. As a closeted actress, that's the last thing Elizabeth needs. If she could just get her dream movie role, life would be so much better. The only problem is that the eccentric French film-maker offering it insists on meeting her "girlfriend", Summer, first.

Captain Sabine Fleischer is a skilled and dedicated US Army surgeon deployed to a combat hospital in Afghanistan. She is also one of the thousands of troops who are forced to serve in silence because of the military's anti-gay policy of "Don't Ask, Don't Tell (DADT)". Usually driven and focused, Sabine finds that battles raging both inside and outside are making it more and more difficult for her to deal with her emotions. Dealing with loss and mortality, lack of privacy, sleep deprivation, loneliness, and the isolation forced on her by Don't Ask, Don't Tell are all taking their toll.

Homicide detective Tori Hunter was used to doing things her way. But even after six different partners in seven years, she was not prepared for the hot-tempered Samantha Kennedy. Samantha, on the other hand, was trying to juggle a new job and a demanding boyfriend and now finds herself with an even greater challenge - being partnered with the most difficult detective in the entire squad.

Personal trainer Rebecca McCall is furious when her coworker is sidelined and she's forced to teach the “Be Your Best Bride” class. As if being a size two for your wedding photos is all for which exercise is good. Could the whole thing get more vain and sexist? The class is full of preening, giggling bridezillas, but one woman stands out: the one who confesses she's only there because her fiancée signed her up. Who does that to someone about whom they care? And why can't Rebecca take her eyes off her?  

Grace Warner spends her days teaching four sections of Beowulf for Cretins to bored students at one of New England's “hidden ivy” colleges. Not long after she is dumped by her longtime girlfriend, Grace meets the engaging and mysterious Abbie on a cross-country flight. Sparks fly on and off the plane as the two strangers give in to one night of reckless passion with no strings attached and no contact information exchanged.

Falling stars are supposed to be a lucky sign, but not for Austen. Her new job as a secretary in an international games company isn't off to a good start. Her first assignment - decorating the Christmas tree in the lobby - results in a trip to the ER after Dee, the company's second-in-command, gets hit by the star-shaped tree topper. Dee blames her instant attraction to Austen on her head wound, not the magic of the falling star. She's determined not to act on it.

Twenty-eight-year-old Brooklyn Campbell is having a bad day. A speeding ticket, a towed car, and a broken heel are all working against her laid-back vibe. To top it all off, her birth mother, whom she's never met, has requested contact. The only bright spot is an impromptu date with a beautiful and mysterious brunette. Jessica Lennox is what you would call a high-powered executive. She's the head of a multimillion-dollar advertising firm in New York City, and it didn't happen by accident.